4 edition of Airways smooth muscle found in the catalog.
Includes bibliographical references and index.
|Statement||edited by D. Raeburn, M.A. Giembycz.|
|Series||Respiratory pharmacology and pharmacotherapy|
|Contributions||Raeburn, D. 1953-, Giembycz, M. A. 1961-|
|LC Classifications||QP121 .A425 1995|
|The Physical Object|
|Pagination||271 p. :|
|Number of Pages||271|
|ISBN 10||3764351403, 0817651403|
|LC Control Number||94048621|
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In this book, leading researchers in medicine and molecular pharmacology explain the cellular mechanisms that control airway smooth muscle. The means by which these are disrupted in disease, and the pharmacologic strategies by which they may be modified are discussed and future therapeutic interventions are identified. All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and relaxation of.
Jan 01, · Asthma is a predisposition to chronic inflammation of the lungs in which the airways (bronchi) are reversibly narrowed. During asthma attacks (exacerbations of asthma), the smooth muscle cells in the bronchi constrict, the airways become inflamed and swollen, and breathing becomes difficult. Asthma affects 7% of the population of the United States. This book is a compendium of up-to-date knowledge in various aspects of physiology and pharmacology of the airways. The current state of the art owes much to the mutual interests of experts from many disciplines. Morphologists, physiologists, biologists, molecular biologists, clinicians, pharmacologists, mathematicians and physicists have all contributed to the study of this virtuosobs.com: Minas Joannides.
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Airway Smooth Muscle in Asthma and COPD is the first book of its kind that focuses entirely on the airway smooth muscle as the prime abnormality in airways diseases such as asthma.
Airways diseases are significant cause of morbidity and mortality across the world, and increasing research into these diseases has developed the understanding of pathophysiological processes in airways disease Author: Kian Fan Chung.
J.S. Fedan, in Reference Module in Biomedical Sciences, Signs and Symptoms. Airway smooth muscle contraction, airway edema, and mucus plugging restrict the passage of air in the airways, making it difficult to virtuosobs.com patient experiences coughing, wheezing, and dyspnea.
Typically the FEV 1 and the peak expiratory flow (PEF) are decreased. Many factors may influence the release of neurotransmitters from airway nerves . This is likely to be important in physiological control of airway functions and may be particularly relevant in airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD).
Neural elements in. Search within book. Front Matter. Pages I-VII. PDF. Anatomy of Airways Smooth Muscle. Giorgio Gabella. Noncholinergic Innervation of Airways Smooth Muscle: Role of Vasoactive Intestinal Peptide and Structurally Related Molecules.
Rolf Uddman, Lars Olaf Cardell, Anders Luts, Frank Sundler. Anatomy of Airways Smooth Muscle / G. Gabella -- 2. Role of the Sympathetic Nervous System and Endogenous Catecholamines in the Regulation of Airways Smooth Muscle Tone / P.
Ind -- 3. Parasympathetic Innervation of Airways Smooth Muscle / B. Canning and B. Undem -- 4. Airways Ganglia / Richard D. Dey -- 5. Get this from a library. Airways Smooth Muscle: Structure, Innervation and Neurotransmission. [David Raeburn; Mark A Giembycz] -- Many factors may influence the release of neurotransmitters from airway nerves .
This is likely to be important in physiological control of airway functions and may be particularly relevant in. Airway smooth muscle is clearly an important target tissue in asthma. An increase in smooth muscle mass is a common feature in both human asthma and experimental models of chronic allergen challenge, and alterations in in vivo smooth muscle responsiveness might be an important determinant of airway hyperresponsiveness.
Airway smooth muscle. Single-unit smooth muscle is found in the walls of hollow organs; multiunit smooth muscle is found in airways to the lungs and large arteries.
Single-unit smooth muscle cells contract synchronously, they are coupled by gap junctions, and they exhibit spontaneous action potential. Modulation of Agonist-Stimulated Phosphoinositide Turnover in Airways Smooth Muscle by Cyclic Nucleotide-Dependent and Independent Mechanisms Pages Challiss, R.
John (et al.). The Role of Airway Smooth Muscle in the Pathogenesis of Airway Wall Remodeling in Chronic Obstructive Pulmonary Disease.
Kian Fan Chung Information on other features of the airway smooth muscle in small airways is not available. Although the airway smooth muscle mass is increased, it is unknown whether this process is caused by an increased Cited by: Physiology of Airway Smooth Muscle Contraction: An Overview.
regulation of airways smooth muscle tone. In Airways of virgin coconut oil on the parameters of airway smooth muscle. Jun 06, · There is broad agreement that, in asthma, increased airway smooth muscle mass, in part due to smooth muscle hyperplasia, is a very significant component of airway remodeling.
However, significant debate persists on the origins of these airway smooth muscle virtuosobs.com by: There is increasing evidence for long-term communication between nerves and smooth muscle cells during development and throughout adult life. To date, the trophic interactions between nerves and airway musculature have attracted little interest, consequently, much of the information presented here is drawn from studies using other smooth muscles.
The airways of mammals are endowed with smooth muscle. The main effects of the contractile activity of this musculature are: i.
to alter the calibre of the airway, hence affecting air pressure and air flow; ii. to alter the rigidity of the airway wall. However, the physiological role of airways smooth muscle is still a matter of speculation .Cited by: 5. Bronchoconstriction is the constriction of the airways in the lungs due to the tightening of surrounding smooth muscle, with consequent coughing, wheezing, and shortness of breath.
Aug 06, · All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle.
Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and Author: Mohamed Trebak. Aug 06, · Smooth muscle cells respond to numerous inputs, including pressure, shear stress, intrinsic and extrinsic innervation, hormones and other circulating molecules, as well as autocrine and paracrine factors.
This book is a review of smooth muscle cell regulation in the cardiovascular, reproductive, GI, and other organ systems with emphasis on Author: Mohamed Trebak, Scott Earley. The respiratory tract is covered in epithelium, which varies down the virtuosobs.com are glands and mucus produced by goblet cells in parts, as well as smooth muscle, elastin or virtuosobs.com of the epithelium (from the nose to the bronchi) is covered in ciliated pseudostratified columnar epithelium, commonly called respiratory epithelium.
The cilia beat in one direction, moving mucus towards FMA: Airway smooth muscle (ASM) extends from the trachea throughout the bronchial tree to the terminal bronchioles.
In utero, spontaneous phasic contraction of fetal ASM is critical for normal lung development by regulating intraluminal fluid movement, ASM differentiation, and release of key growth virtuosobs.com by: 1.
Respiratory Smooth Muscle; Deep to the lamina propria lies a band of smooth muscle forming the bronchial smooth muscle. While absent from the trachea, the smooth muscle layer gradually increases in thickness as airways branch and is used regulate the diameter and in turn the resistance of the airways to airflow.
Respiratory Submucosa. Respiratory Smooth Muscle Layer: A band of smooth muscle cells, forming the bronchial smooth muscle, lies deep to the lamina propria.
While absent from the trachea, the layer gradually increases in thickness as airways branch. This band of smooth muscle is used to regulate the diameter of the airways, which consequently modulates their.The Molecular Basis for the Gain in Contractile Capacity Elicited by Tone in Airway Smooth Muscle Morgan Gazzola, Audrey Lee-Gosselin, Laurence Auger, Katherine Lortie, Marie-Renée Blanchet.
A link between airway smooth muscle (ASM) and airway hyperresponsiveness (AHR) in asthma was first postulated in the midnineteenth century, and the suspected link has garnered ever increasing interest over the years.
AHR is characterized by excessive narrowing of airways in response to nonspecific stimuli, and it is the ASM that drives this narrowing. The stimuli that can be used to Cited by: 4.